Inhibition of Human Neutrophil Elastase by Sesquiterpene Lactone Dimers from the Flowers of Inula britannica
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Novel Sesquiterpene Lactone and Sesquiterpene Lactone Glucoside from the Flowers of the Tunisian Pulicaria Laciniata (coss. Et Kral.) Thell
* corresponding author, e-mail : [email protected] Abstract: A sesquiterpene lactone 1 Lacinin and a sesquiterpene lactone glucoside 2 Laciniside, were isolated from the flowers of Pulicaria laciniata. Their structures were elucidated by extensive spectroscopic methods including 1D-( 1 H and 13 C) and 2D-NMR experiments, (CHcorr, HMBC, 1 H1 H COSY and NOESY) as well as high resolution E...
متن کاملAcylated flavonol glycosides from the flower of Inula britannica.
Three new acylated flavonol glycosides, patuletin 7-O-(6' '-isobutyryl)glucoside (1), patuletin 7-O-[6' '-(2-methylbutyryl)]glucoside (2), and patuletin 7-O-(6' '-isovaleryl)glucoside (3), were isolated from the n-BuOH extract of Inula britannica flowers by bioassay-guided fractionation, together with other known flavonoids. The structures were elucidated by 1D and 2D NMR, FABMS, and other spec...
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Compounds that inhibit aromatase activity are used for the treatment of breast cancer. A group of sesquiterpene lactones inhibit aromatase activity and also exert cytotoxicity through their reactive alpha-methylene-gamma-lactone group. To synthesize sesquiterpene lactones with greater specificity for aromatase inhibition and lower cytotoxicity, we chemically reduced the alpha-methylene-gamma-la...
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ژورنال
عنوان ژورنال: Journal of Microbiology and Biotechnology
سال: 2018
ISSN: 1017-7825,1738-8872
DOI: 10.4014/jmb.1807.07039